https://doi.org/10.1140/epjp/s13360-023-04796-3
Regular Article
Rabies-related brain disorders: transmission dynamics and epidemic management via educational campaigns and application of nanotechnology
1
Mechanical Engineering Department, College of Engineering and Islamic Architecture, Umm Al-Qura University, P. O. Box 5555, 21955, Makkah, Saudi Arabia
2
Department of Mathematics, University of the Punjab, 54590, Lahore, Pakistan
3
School of Mechanical Engineering and Automation, Harbin Institute of Technology, 518055, Shenzhen, China
Received:
19
October
2023
Accepted:
13
December
2023
Published online:
16
January
2024
This study introduces an innovative approach to understand better and address rabies transmission-causing brain disorders by developing a comprehensive mathematical model, and the model’s credibility is verified through the utilization of real-world data of confirmed rabies cases. The model meticulously examines the dynamics of rabies transmission, rabies-free equilibrium stability, parameter estimation, and the basic reproductive number. Furthermore, sensitivity analysis identifies pivotal factors influencing transmission, while 3D surface plots illustrate the effects of threshold parameters on the basic reproduction number. An extensive review of literature and case studies reinforces the strong association between rabies and severe neurological disorders, underscoring the urgent need for effective epidemic management. Control strategies such as educational campaigns and utilization of nanotechnology are proposed and analyzed to combat this threat. The ultimate goal is to enhance the prompt identification, treatment, and mitigation of rabies, strengthening response to brain-disabling outbreaks.
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© The Author(s), under exclusive licence to Società Italiana di Fisica and Springer-Verlag GmbH Germany, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
