https://doi.org/10.1140/epjp/s13360-023-03732-9
Regular Article
Analyzing the diffusion and duration of antibodies to SARS-CoV-2 during the natural infection and comparison with vaccination
1
IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089, Rozzano, MI, Italy
2
Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, 20072, Pieve Emanuele, MI, Italy
Received:
31
March
2022
Accepted:
22
January
2023
Published online:
9
February
2023
To monitor SARS-CoV-2 diffusion, we measured anti-Spike S1/S2 IgGs in the serum of nearly 4000 workers employed in several healthcare facilities for one year. We found that the antibody response persists at least over 8 months in symptomatic subjects, particularly in individuals with anosmia/dysgeusia. Moreover, analyzing a smaller cohort (124 healthcare employees of which 57 had a previous history of SARS-CoV-2 exposure) vaccinated with two doses of Comirnaty vaccine, we observed that in symptomatic subjects previously exposed to SARS-CoV-2 one dose vaccine was sufficient to stimulate very high levels of antibodies, suggesting that these subjects should take only one dose of vaccine.
Focus Point on Progress in Medical Physics in Times of CoViD-19 and Related Inflammatory Diseases. Guest editors: E. Cisbani, S. Majewski, A. Gori, F. Garibaldi.
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© The Author(s), under exclusive licence to Società Italiana di Fisica and Springer-Verlag GmbH Germany, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
