https://doi.org/10.1140/epjp/s13360-023-03731-w
Regular Article
The role of Zn ions in the interaction between SARS-CoV-2 orf7a protein and BST2/tetherin
1
Università di Roma “Tor Vergata” and INFN, Sezione di Roma 2 - Via della Ricerca Scientifica 1, 00133, Rome, Italy
2
Dipartimento di Biochimica, Sapienza Universitá di Roma, Piazzale Aldo Moro 5, 00185, Rome, Italy
3
CNR, Institute for Chemistry of Organometallic Compounds, 50019, Sesto Fiorentino, Italy
4
ENEA CR Frascati, Diagnostics and Metrology Laboratory FSN-TECFIS-DIM, Via E. Fermi, 45, 00044, Frascati, Italy
5
Observatoire des Sciences de l’Univers de Grenoble, UMS 832 CNRS, Université Grenoble Alpes, 38041, Grenoble, France
6
Centro Fermi - Museo Storico della Fisica e Centro Studi e Ricerche Enrico Fermi, Via Panisperna 89a, 00184, Roma, Italy
k
silvia.morante@roma2.infn.it
Received:
23
March
2022
Accepted:
22
January
2023
Published online:
8
March
2023
In this paper, we provide evidence that Zn
ions play a role in the SARS-CoV-2 virus strategy to escape the immune response mediated by the BST2-tetherin host protein. This conclusion is based on sequence analysis and molecular dynamics simulations as well as X-ray absorption experiments [1].
Focus Point on Progress in Medical Physics in Times of CoViD-19 and Related Inflammatory Diseases. Guest editors: E. Cisbani, S. Majewski, A. Gori, F. Garibaldi.
© The Author(s) 2023
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