https://doi.org/10.1140/epjp/s13360-024-05684-0
Regular Article
A mathematical model of HMGB1 release in single-cell
Department of Mathematics Bioinformatics and Computer Applications, Maulana Azad National Institute of Technology, 462003, Bhopal, Madhya Pradesh, India
a
kuldeepsinghyadavy@gmail.com
Received:
21
August
2024
Accepted:
24
September
2024
Published online:
23
October
2024
This paper presents a mathematical model to study release dynamics of High Mobility Group Box 1 (HMGB1) protein post-irradiation at the cellular scale. HMGB1, a damage-associated molecular pattern (DAMP) molecule, plays a crucial role in inflammation and immune responses, particularly in cancer progression and modulating therapies. Our model simulates the translocation of HMGB1 from the cytosol to the extracellular matrix (ECM), accounting for key factors such as cell membrane permeability, cell size and shape, and diffusivity of the HMGB1 molecule. We discuss the effects of radiation-induced enhanced membrane permeability, leading to increased HMGB1 release over time. Additionally, our results highlight the influence of cell size and shape on HMGB1 release and distribution into extracellular matrix, with larger and elongated cells promoting localized pro-inflammatory environment in tumor. Using this model, the prediction of HMGB1 release dynamics under various conditions, may aid in the design of experiments and therapeutic strategies aimed at modulating HMGB1’s role in cancer treatment, inflammation, and immune responses.
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© The Author(s), under exclusive licence to Società Italiana di Fisica and Springer-Verlag GmbH Germany, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
