https://doi.org/10.1140/epjp/s13360-024-05502-7
Regular Article
Economic evaluation of a two-strain Hepatitis C vaccination model in Bangladesh using optimal control technique
1
Department of Mathematics, University of Rajshahi, 6205, Rajshahi, Bangladesh
2
School of Computing, Mathematics and Engineering, Charles Sturt University, 2678, Wagga Wagga, NSW, Australia
Received:
22
May
2024
Accepted:
25
July
2024
Published online:
5
August
2024
Hepatitis C virus (HCV) is a leading cause of morbidity and mortality worldwide, including in Bangladesh. Although the Ministry of Health in Bangladesh is implementing its nationwide HCV control policies, more specific and cost-effective interventions are needed to control HCV. In this study, we developed a two-strain HCV vaccination model to explore the dynamics of HCV infection transmission in Bangladesh. We calibrated the model with the number of HCV cases in Bangladesh to estimate some setting-specific parameters. We also derived the basic reproduction numbers (R01 and R02) and performed contour plots to find the most significant parameters and found that the transmission rate had the largest impact on HCV dynamics. We evaluated the cost-effectiveness of three basic control strategies: transmission control, vaccination, and treatment, all within the optimal control context. Our findings suggested that a triple control strategy combining transmission control, vaccination, and treatment is the most cost-effective way to reduce the burden of HCV. Our finding also indicated that the transmission control strategy is the most cost-effective for the single intervention strategies compared to vaccination and treatment. Alternative programmes can be adopted to curb HCV, depending on the availability of resources and policymakers' decisions.
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© The Author(s), under exclusive licence to Società Italiana di Fisica and Springer-Verlag GmbH Germany, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
