https://doi.org/10.1140/epjp/s13360-024-05360-3
Regular Article
Highly sensitive photonic crystal fiber optic sensor for cancer cell detection
1
College of Electrical Engineering, North China University of Water Resources and Electric Power, 450045, Zhengzhou, China
2
College of Electronic and Optical Engineering & College of Flexible Electronics (Future Technology), Nanjing University of Posts and Telecommunications, 210023, Nanjing, China
3
College of Precision Instrument and Opto-electronics Engineering, Institute of Laser and Opto-electronics, Tianjin University, 300072, Tianjin, China
Received:
4
April
2024
Accepted:
10
June
2024
Published online:
24
June
2024
The prognosis for cancer prevention and control is dire as it has emerged as one of the primary illnesses that poses a serious threat to human health. In 2022, the global number of new cancer cases will be 19.29 million, while the number of new cancer cases in China will be 4.57 million, accounting for 23.7 percent of the total number of new cancer cases worldwide. The differentiation in refractive indices between normal and cancerous cells enables the assessment of loss curve fluctuations to identify the extent of cancer. Consequently, this article presents a photonic crystal fiber optic sensor with exceptional sensitivity as a means of detecting cancer cells. Using the finite element method, one can parametrically analyze the thickness of the gold nanofilm in the sensor, the diameter of the U-channel, and the three comparatively small air openings in the fiber core. In the refractive index detection range of 1.33–1.43, the simulation results indicate that the sensor has a maximum wavelength sensitivity of 26,900 nm/RIU, an optimal resolution of 3.72 × 10−6 RIU, and a maximum quality factor of 126.96 RIU−1. The sensor has a high sensitivity, a wide range of refractive index detection, a simple structure, and easy pulling, which is potentially useful for bioanalysis, and medical diagnosis It has potential applications in bioanalysis, medical diagnosis, and clinical trials.
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© The Author(s), under exclusive licence to Società Italiana di Fisica and Springer-Verlag GmbH Germany, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
