https://doi.org/10.1140/epjp/s13360-023-03749-0
Regular Article
Design and numerical investigation of a dual-core photonic crystal fiber refractive index sensor for cancer cells detection
1
Nano-Photonic and Optoelectronic Research Laboratory (NORLab), Shahid Rajaee Teacher Training University, 16788-15811, Tehran, Iran
2
Faculty of Electrical Engineering, Shahid Rajaee Teacher Training University, 16788-15811, Tehran, Iran
Received:
25
November
2022
Accepted:
26
January
2023
Published online:
6
February
2023
A double-core photonic crystal fiber (PCF) based refractive index sensor is introduced to detect six different cancer-affected cells. A comparatively large air hole is considered in the middle of the fiber to be injected with fluids of normal and cancer-affected cells. Transmission length, the diameter of the air hole filling with samples, and the diameter of two other important air holes are studied in this work to attain a more appropriate performance of the presented sensor. The performance of the suggested sensor is studied by analyzing the variations in the transmission spectrum because of changes in the normal and affected cell refractive indices. The results display that the proposed sensor attains spectral sensitivities of 10,000 nm/RIU, 11,250 nm/RIU, 10,714.28 nm/RIU, 12,857.14 nm/RIU, 11,428.57 nm/RIU, and 12,500 nm/RIU corresponding to Basal cell cancer, cervical cancer HeLa cells, Jurkat cancer cell, PC12 cancer cell, MDA-MB-231 breast cancer cell, and MCF-7 breast cancer cell, respectively. Also, resolution as an important parameter in sensors evaluation is studied and the obtained results are 
, 
, 
, 
, 
, and 
for the above-mentioned cells, respectively. Moreover, the maximum FOM value achieved for the reported biosensor is 22.03 1/RIU for the Basal cell. The proposed refractive index sensor can be implemented to detect different cancer cells because of its high sensitivity and simple design.
© The Author(s), under exclusive licence to Società Italiana di Fisica and Springer-Verlag GmbH Germany, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
