https://doi.org/10.1140/epjp/s13360-023-04813-5
Regular Article
Analysing the probable insights of ADE in dengue vaccination embodying sequential Zika infection and waning immunity
Department of Engineering Sciences, ABV-Indian Institute of Information Technology and Management Gwalior, Gwalior, MP, India
Received:
24
October
2023
Accepted:
19
December
2023
Published online:
2
January
2024
Virus-specific antibodies are contemplated as antiviral and significantly contribute to preventing viral infections. In certain circumstances, the occupancy of specific antibodies may perk the virus infection under the influence of the antibody-dependent enhancement (ADE) factor. This study examines the potential impact of ADE on the sequential Zika infection against dengue vaccination and waned immunity cases through mathematical modeling. The basic reproduction number is calculated via the next-generation matrix method. Further, the global stability of the disease-free equilibrium point is established by employing the Kamgang–Sallet theorem. The partial rank correlation coefficient and Latin hypercube sampling global sensitivity index methods have been employed to determine the influential parameters of the model. The analytical findings and numerical simulations suggested that dengue vaccination may help control the disease in primary infected cases while it exerts a negative impact on sequential Zika infection. Lastly, we provide a numerical application to Espirito Santo, a state in Brazil to support our findings. The proposed model is fitted to the extracted data for the period of February 14, 2021, to June 29, 2021. It is observed that if the ADE parameter is increased by 
and 
from its baseline value, then the sequential Zika infection cases also increased by 10% and 14% respectively, and the system attains its peak on prior. Our results suggest that existing immunity to DENV may enhance the replication of ZIKV, with significant implications for understanding disease mechanisms and developing future ZIKV vaccine strategies.
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© The Author(s), under exclusive licence to Società Italiana di Fisica and Springer-Verlag GmbH Germany, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
