https://doi.org/10.1140/epjp/s13360-025-06000-0
Regular Article
A brief study of the effects of magnesium divalent ions on the Dickerson DNA sequence at varying molar concentrations
1
School of Computational and Integrative Science, Jawaharlal Nehru University, New Delhi, 110067, India
2
Department of Physics and Astrophysics, University of Delhi, New Delhi, 110007, India
a
rkumarmishra@physics.du.ac.in
Received:
4
October
2024
Accepted:
10
January
2025
Published online:
22
January
2025
The interaction of nucleic acids with metallic ions is crucial for DNA function. Mg2+ can bond directly or indirectly via water. We explored Mg2+ interaction with Dickerson DNA at varying Mg2+ concentrations with fixed NaCl concentration. Analysing the correlation function, we mapped Mg2+ density around DNA regions. We found that the Mg2+ interaction decreased with rising Mg2+ concentrations. Mg2+ also displayed a higher affinity for the Phosphate group over grooves. We explored the variation of stacking parameters by varying Mg2+ concentrations, indicating slight structural changes which have not been explored yet. Our study reflects that the Mg2+ concentrations had almost minimal impact on Dickerson-DNA structure, instead stabilizing it.
Copyright comment Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
© The Author(s), under exclusive licence to Società Italiana di Fisica and Springer-Verlag GmbH Germany, part of Springer Nature 2025
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
