https://doi.org/10.1140/epjp/s13360-024-05843-3
Regular Article
Sensitivity study of the development modified microdosimetric kinetic model input parameters for proton beam therapy
Department of Physics, Faculty of Science, University of Guilan, 41335-1914, Rasht, Iran
b p.taherparvar@guilan.ac.ir, p.taherparvar@gmail.com
Received:
14
March
2024
Accepted:
14
November
2024
Published online:
28
November
2024
In the development of modified microdosimetric kinetic model (DMMKM), by considering the concept of DNA double-strand breaks (DSBs), the relative biological effectiveness (RBE) calculations can better explain the published experimental results than the microdosimetric kinetic model (MKM) in the proton therapy. In this paper, a sensitivity study was done on the MKM and DMMKM input parameters. Comparisons in terms of the biological dose and the α parameter of a linear-quadratic (LQ) model were performed using the MKM and DMMKM with nominal and varied V79 (Chinese hamster lung fibroblast cell line) parameters for proton beams. Moreover, the effects of varying the MKM and DMMKM input parameters on the deviations from the experimental data of α and D10 (10% V79 cell survival fraction dose) have been studied for proton beams. Among the MKM (DMMKM) input parameters, differences in α0 (A) have the largest effect and differences in Rn a negligible effect on the biological dose in proton beams. The changes in α calculated with the DMMKM due to variations in input parameters are comparable or smaller than those obtained with the MKM throughout the proton beam range. Consequently, inaccuracies in the MKM input parameters result in higher differences in the RBE calculations when compared to the DMMKM. Since the variations in rd parameter result in a significant deviation from the experimental data of D10, the importance of applying the correct input parameter values in patient treatment becomes apparent.
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© The Author(s), under exclusive licence to Società Italiana di Fisica and Springer-Verlag GmbH Germany, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
