https://doi.org/10.1140/epjp/s13360-024-05224-w
Regular Article
Fast X-ray ptychography: towards nanoscale imaging of large volume of brain
1
Department of Medical Physics and Biomedical Engineering, University College London, Malet Place Engineering, Gower St, WC1E 6BT, London, UK
2
Institute of Nanotechnology, CNR-Nanotec, Piazzale Aldo Moro 5, 00185, Rome, Italy
3
Santa Lucia Foundation, via Ardeatina 356, 00179, Rome, Italy
4
Cardiff University Brain Research Imaging Centre, Cardiff University, Maindy Road, CF24 4HQ, Cardiff, UK
5
DECTRIS Ltd., Taefernweg 1, 5405, Baden-Daettwil, Switzerland
6
BioPhantoms Ltd., Watson House, 4 Mill Park, CB1 2FH, Cambridge, UK
7
Bioxydyn Limited, St James Tower, 7 Charlotte Street, M1 4DZ, Manchester, UK
8
Diamond Light Source, Harwell Science and Innovation Campus, Fermi Avenue, OX11 0DE, Didcot, UK
Received:
19
December
2023
Accepted:
28
April
2024
Published online:
21
May
2024
X-ray ptychography, a scanning coherent diffraction imaging technique, is one of the most used techniques at synchrotron facilities for high resolution imaging, with applications spanning from life science to nano-electronics. In the recent years there has been a great effort to make the technique faster to enable high throughput nanoscale imaging. Here we apply a fast ptychography scanning method to image in 3D of brain-like phantom at 3 kHz, in a 7 h acquisition with a resolution of 270 nm. We then present the latest advances in fast ptychography by showing 2D images acquired at 110 kHz by combining the fast-acquisition scheme with a high-acquisition rate prototype detector from DECTRIS Ltd. We finally review the experimental outcome and discuss the prospective use of fast ptychography schemes for the investigation of mm
size samples of brain-like phantom, by extrapolating the current results to the high coherent flux scenario of diffraction limited storage rings.
Silvia Cipiccia and Darren J. Batey have contributed equally to this work.
Supplementary Information The online version contains supplementary material available at https://doi.org/10.1140/epjp/s13360-024-05224-w.
© The Author(s) 2024
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