https://doi.org/10.1140/epjp/s13360-023-04508-x
Regular Article
Computational investigations of the 
and TGF-
dynamics in a fibroblast cell
DoM, Sardar Vallabhbhai National Institute of Technology, 395007, Surat, Gujarat, India
Received:
8
June
2023
Accepted:
20
September
2023
Published online:
3
October
2023
Transforming growth factor- (TGF-) is a crucial regulator of fibroblast cell function and is essential for maintaining and repairing connective tissues in the body. Calcium 
signaling is essential for regulating TGF- concentrations in fibroblasts. Changes in the various mechanisms of calcium-dependent kinetics can disrupt TGF- regulation in fibroblast cells. However, no model is available to date about the spatiotemporal relationships of TGF- regulation and dynamics in fibroblasts. We propose a coupled reaction–diffusion model for the one-way feedback between spatiotemporal and TGF- dynamics in fibroblasts. The Crank–Nicholson with the finite element method (FEM) is used for the simulation. The numerical results provide insights into the buffer, source influx, and diffusion effects on the dynamics of and TGF- in fibroblasts. Disturbances in the one-way cooperative dynamics of and TGF- can cause fibrotic diseases like fibrosis and cancer.
Copyright comment Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
© The Author(s), under exclusive licence to Società Italiana di Fisica and Springer-Verlag GmbH Germany, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
