Quantitative SERS method on a colloid at the initial stage of rapid coagulation
N.M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, 119334, Moscow, Russian Federation
Accepted: 3 August 2022
Published online: 10 August 2022
Quantitative analysis of substances by SERS always assumes a correlation between the concentration of the substance and the characteristic peak intensity, but this article proposes an alternative new approach based on the dependence of the concentration of substances on the growth rate of the characteristic peak intensity at the beginning of rapid coagulation of colloid. The theoretical basis of the proposed method is presented, and the features and problems of its implementation are considered. The proposed quantitative SERS method allows not only to accurately measure the content of substances in the medium, but also makes it possible to determine the affinity coefficients for the interaction of analytes and colloidal nanoparticles.
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