Multifunctional radioactive ZnO/NiFe2O4 nanocomposite for theranostic applications
Cyclotron Facility, Nuclear Physics Department, Nuclear Research Center, Egyptian Atomic Energy Authority, 13759, Cairo, Egypt
2 Physics Department, Faculty of Science, Zagazig University, Zagazig, Egypt
Accepted: 12 October 2021
Published online: 8 November 2021
A new approach is presented in this work for using developed nanomagnetic particles for magnetic hyperthermia and radio-diagnostic applications. A set of ZnO/Ni-ferrite composites were prepared with different concentrations of NiFe2O4 (0–25 wt%) in addition to pure ZnO and Ni-ferrite samples, using sol–gel technique. The samples were subjected to AC magnetic field to measure their specific absorption rate (SAR). It was noticed that the determined SAR increased from 6.5 W/g at 5 wt% to 110 W/g at 25 wt%, which represents about 40% of that for pure NiFe2O4. The sample of 15 wt% Ni-ferrite was selected for irradiation with 14.7 MeV proton beam at the cyclotron to convert some of its constituents to diagnostic radioisotopes. As a result of proton-induced reactions on Zn and Ni, several short-lived medical radioisotopes were produced such as 68Ga (67.6 min), 66Ga (9.4 h), 67Ga (78.3 h) and 61Cu (3.3 h). The irradiated sample was analyzed at short and long cooling periods post-irradiation using high-resolution γ-ray spectroscopy coupled with high purity Ge detector. Based on the decay data, all the γ-ray spectral lines were identified and correlated with their origin. Then, the radioactivity at end of bombardment for each isotope was determined. The radioactive yields for positron emitters 68Ga (263.86 MBq/µA h) and 66Ga (33 MBq/µA h) were the highest values. Very low activity levels were detected for the other medium and long half-life radioisotopes (0.03–5 MBq/µA h). The combined magnetic properties and radiotracer isotopes in the prepared composites may allow a novel methodology for simultaneous treatment and diagnostic of cancer cells.
© The Author(s), under exclusive licence to Società Italiana di Fisica and Springer-Verlag GmbH Germany, part of Springer Nature 2021