Changes in blood–brain barrier permeability characterized from electroencephalograms with a combined wavelet and fluctuation analysis
Saratov State University, Astrakhanskaya 83, 410012, Saratov, Russia
2 Potsdam Institute for Climate Impact Research, Telegraphenberg A 31, 14473, Potsdam, Germany
3 Institute of Physics, Humboldt University Berlin, 12489, Berlin, Germany
Accepted: 19 May 2021
Published online: 25 May 2021
We study changes in the blood–brain barrier (BBB) permeability in mice caused by a 2-h intermittent sound and discuss their reflection in the electrical activity of the brain. Using the detrended fluctuation analysis (DFA), multiresolution wavelet analysis (MWA) and their recent modifications, we compare the capabilities of reliably characterizing the transitions between closed and open BBB states. It is shown that an enhanced approach, combining MWA with DFA of the decomposition coefficients, improves the interstate separation by limiting the most appropriate level of resolution. This approach can be useful in various studies of complex systems based on experimental data.
© The Author(s), under exclusive licence to Società Italiana di Fisica and Springer-Verlag GmbH Germany, part of Springer Nature 2021