Effect of non-cytolytic cure and saturation response: An in silico study to instigate the viral spread inhibition
Department of Mathematics, National Institute of Technology Agartala, Jirania, Tripura, India
* e-mail: firstname.lastname@example.org
Accepted: 24 April 2020
Published online: 19 May 2020
The non-cytolytic cure of infected cells is an imperative mechanism that maintains the healthy state in the host body by reducing the level of infection. The primary purpose of humoral immune response, i.e., the B cell response, is to neutralize the extracellular virions present in the body. To explore the impact of infected cells and virus particle-mediated saturation response on the viral spread dynamics under the influence of these critical factors, we propose a viral infection model incorporating the coupling effect of non-cytolytic cure mechanism and saturation response in the presence of humoral immune responses. Through parameter variation experimentation, we obtain that under the exposure of a weak humoral response, the saturation response effectively reduces the level of virions, whereas it has a less significant effect on viral infection dynamics in the presence of a strong humoral response or non-cytolytic cure mechanism. We observe that the strength of humoral immune response depends on the number of activated B cells present in the body rather than the rate at which it neutralizes the viruses. Further, we demonstrate that the non-cytolytic cure mechanism plays a vital role in restoring the no infection phase in the host body in the presence of a high infection coefficient. Moreover, a case study of HCV-infected human hepatic Huh7.5.1 cell lines has been presented to describe the HCV infection dynamics in a real-life scenario using model prediction technique.
© Società Italiana di Fisica and Springer-Verlag GmbH Germany, part of Springer Nature, 2020