Eur. Phys. J. Plus (2017) 132: 288
https://doi.org/10.1140/epjp/i2017-11566-9

Regular Article

Continuous and discontinuous phase transitions in the evolution of a polygenic trait under stabilizing selective pressure

¹ CNR-SPIN Complesso, Univ. Monte S. Angelo, Via Cinthia, I-80126, Napoli, Italy
² Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli “Federico II”, Napoli, Italy
³ Istituto di Endocrinologia ed Oncologia Sperimentale, CNR Napoli, Napoli, Italy
⁴ INFN, Sezione di Napoli, Complesso Univ. Monte S. Angelo, Via Cinthia, I-80126, Napoli, Italy
⁵ Dipartimento di Fisica “Ettore Pancini”, Università degli Studi di Napoli “Federico II”, Napoli, Italy

^* e-mail: annalisa.fierro@spin.cnr.it

Received: 28 March 2017
Accepted: 22 May 2017
Published online: 30 June 2017

Abstract

The presence of phenomena analogous to phase transition in Statistical Mechanics has been suggested in the evolution of a polygenic trait under stabilizing selection, mutation and genetic drift. By using numerical simulations of a model system, we analyze the evolution of a population of N diploid hermaphrodites in random mating regime. The population evolves under the effect of drift, selective pressure in form of viability on an additive polygenic trait, and mutation. The analysis allows to determine a phase diagram in the plane of mutation rate and strength of selection. The involved pattern of phase transitions is characterized by a line of critical points for weak selective pressure (smaller than a threshold), whereas discontinuous phase transitions, characterized by metastable hysteresis, are observed for strong selective pressure. A finite-size scaling analysis suggests the analogy between our system and the mean-field Ising model for selective pressure approaching the threshold from weaker values. In this framework, the mutation rate, which allows the system to explore the accessible microscopic states, is the parameter controlling the transition from large heterozygosity (disordered phase) to small heterozygosity (ordered one).