https://doi.org/10.1140/epjp/s13360-025-07277-x
Regular Article
Enhanced antibacterial action against Pseudomonas aeruginosa via the electromechanical synergy of nanocurcumin mesoporous silica and piezoelectric PVDF nanofibers
1
Physics and Chemistry Department, Faculty of Education, Alexandria University, 21544, Alexandria, Egypt
2
Physics Department, Faculty of Science, Alexandria University, 21544, Alexandria, Egypt
3
Basic Sciences Department, Faculty of Engineering, Pharos University in Alexandria, 21544, Alexandria, Egypt
a
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Received:
7
November
2025
Accepted:
29
December
2025
Published online:
13
January
2026
Abstract
Despite its therapeutic potential, curcumin suffers from poor solubility and low bioavailability. This study overcomes these limitations by developing a multifunctional nanocomposite of nanocurcumin, mesoporous silica, and piezoelectric PVDF nanofibers. By leveraging the electromechanical response of PVDF, mechanical strain generates weak electric impulses that synergistically enhance antibacterial activity. Results demonstrate an exceptional 4.2-log reduction (99.99% kill) of Pseudomonas aeruginosa, significantly outperforming individual components. This synergy is driven by piezoelectric pulses acting as a critical external cofactor, evidenced by an extended bacterial lag phase, minimized stress efficiency index, and a 16-fold increase in phospholipase leakage. These findings confirm that electrostatically induced permeability changes compromise cellular integrity, successfully augmenting curcumin’s antimicrobial efficacy for targeted wound healing.
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© The Author(s), under exclusive licence to Società Italiana di Fisica and Springer-Verlag GmbH Germany, part of Springer Nature 2026
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
